Abstract
Polyphenols constitute a group of a paramount importance within the natural products in the plant kingdom, with an approximate amount of 8000 phenolic structures currently known. Fruits, vegetables, whole grains and several other foods and beverages (as tea, chocolate and wine, for instance) are rich and important sources of polyphenols. The scientific literature provides pre-clinical experimental evidence on the antinociceptive effects of polyphenolic compounds, found in plant extracts, in animal models of neuropathic pain. But not only neuropathic pain is attenuated: in fact, nociceptive pain, caused by stimulation of nerve fibers (either somatic or visceral) responding only to stimuli approaching or exceeding harmful intensity thresholds (nociceptors), and also inflammatory pain, which is associated with tissue damage and infiltration of immune cells, are both reduced and alleviated by polyphenols. In the present work, the antinociceptive effects of polyphenols are reviewed.
Keywords: Pain, baicalin, pueranin, myricitrin, epigallocatechin gallate, curcumin, resveratrol.
Current Drug Targets
Title:New Pharmacological Approaches Using Polyphenols on the Physiopathology of Neuropathic Pain
Volume: 18 Issue: 2
Author(s): Pere Boadas-Vaello, Jose Miguel Vela and Enrique Verdu
Affiliation:
Keywords: Pain, baicalin, pueranin, myricitrin, epigallocatechin gallate, curcumin, resveratrol.
Abstract: Polyphenols constitute a group of a paramount importance within the natural products in the plant kingdom, with an approximate amount of 8000 phenolic structures currently known. Fruits, vegetables, whole grains and several other foods and beverages (as tea, chocolate and wine, for instance) are rich and important sources of polyphenols. The scientific literature provides pre-clinical experimental evidence on the antinociceptive effects of polyphenolic compounds, found in plant extracts, in animal models of neuropathic pain. But not only neuropathic pain is attenuated: in fact, nociceptive pain, caused by stimulation of nerve fibers (either somatic or visceral) responding only to stimuli approaching or exceeding harmful intensity thresholds (nociceptors), and also inflammatory pain, which is associated with tissue damage and infiltration of immune cells, are both reduced and alleviated by polyphenols. In the present work, the antinociceptive effects of polyphenols are reviewed.
Export Options
About this article
Cite this article as:
Boadas-Vaello Pere, Vela Miguel Jose and Verdu Enrique, New Pharmacological Approaches Using Polyphenols on the Physiopathology of Neuropathic Pain, Current Drug Targets 2017; 18 (2) . https://dx.doi.org/10.2174/1389450117666160527142423
DOI https://dx.doi.org/10.2174/1389450117666160527142423 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Molecular Pathophysiology of Cavernous Nerve Injury and Identification of Strategies for Nerve Function Recovery After Radical Prostatectomy
Current Drug Targets Subject Index to Volume 10
Current Pharmaceutical Design Painful Peripheral Neuropathies
Current Neuropharmacology Doppler Haemodynamics of Cerebral Venous Return
Current Neurovascular Research Molecular and Epigenetic Basis of Extracellular Vesicles Cell Repair Phenotypes in Targeted Organ-specific Regeneration
Current Molecular Medicine Current Management of Chordoma
Current Drug Therapy Cardiovascular Alterations After Spinal Cord Injury: An Overview
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Oxytocin and Diabetes Mellitus: A Strong Biochemical Relation. Review
Current Diabetes Reviews The Role of Proprioception in Osteoarthritis of the Hand and Wrist
Current Rheumatology Reviews Role of α- and β-adrenergic Mechanisms in the Pathogenesis of Pulmonary Injuries Characterized by Edema, Inflammation and Fibrosis
Cardiovascular & Hematological Disorders-Drug Targets Recent Patents on Cell-based Approaches to Collagen Enrichment and Repair
Recent Patents on Regenerative Medicine Editorial
Current Medical Imaging Vertebral Lesions from AIDS-Related Kaposi's Sarcoma
Current HIV Research Adult Stem Cell Application in Spinal Cord Injury
Current Drug Targets Animal Models Used for Testing Hydrogels in Cartilage Regeneration
Current Stem Cell Research & Therapy Lung Volume Reduction in Patients with COPD: Physiological and Clinical Implications
Current Respiratory Medicine Reviews Recent Advances in Treatment Approaches of Mucopolysaccharidosis VI
Current Pharmaceutical Biotechnology Multiple Roles of Transient Receptor Potential (TRP) Channels in Inflammatory Conditions and Current Status of Drug Development
Current Topics in Medicinal Chemistry Advances in Hydrogels Applied to Degenerative Diseases
Current Pharmaceutical Design Bisphosphonates as Treatment of Bone Metastases
Current Pharmaceutical Design