Histaminergic System and Vestibular Function in Normal and Pathological Conditions

Title:Histaminergic System and Vestibular Function in Normal and Pathological Conditions

Volume: 22 Issue: 11

Author(s): Brahim Tighilet*, Jessica Trico, Emna Marouane, Andreas Zwergal and Christian Chabbert

Affiliation:

• Aix Marseille Université-CNRS, Laboratoire de Neurosciences Cognitives, LNC UMR 7291, Marseille, France, Groupe de Recherche Vertige (GDR#2074)

Keywords: Vestibular system, histaminergic system, vestibular disorders, neuroinflammation, histaminergic drugs, vertigo.

Abstract: Most neurotransmitter systems are represented in the central and peripheral vestibular system and are thereby involved both in normal vestibular signal processing and the pathophysiology of vestibular disorders. However, there is a special relationship between the vestibular system and the histaminergic system. The purpose of this review is to document how the histaminergic system interferes with normal and pathological vestibular function. In particular, we will discuss neurobiological mechanisms such as neuroinflammation that involve histamine to modulate and allow restoration of balance function in the situation of a vestibular insult. These adaptive mechanisms represent targets of histaminergic pharmacological compounds capable of restoring vestibular function in pathological situations. The clinical use of drugs targeting the histaminergic system in various vestibular disorders is critically discussed.

Cite this article as:

Tighilet Brahim*, Trico Jessica, Marouane Emna, Zwergal Andreas and Chabbert Christian, Histaminergic System and Vestibular Function in Normal and Pathological Conditions, Current Neuropharmacology 2024; 22 (11) . https://dx.doi.org/10.2174/1570159X22666240319123151